In the independent Yale-Penn 3 sample16 (EUR n=1,986), the addiction-rf PRS was significantly associated with a phenotypic factor loading on several SUDs (p<.001), polysubstance use disorder (2 or more substance use disorders; p<2e-16), and each individual SUD (DSM-IV29: AUD, CUD, OUD, tobacco dependence or TD, and cocaine use disorder [CoUD] (all ps < 7.71E-06; Figure 4; Supplemental Table 20). Nagelkerke’s R2 values ranged from 2.4% for CUD to 5.9% for TD, and 6.6% for a phenotype similar to addiction-rf that represents phenotypic commonality across AUD, CUD, OUD, TD and CoUD. Odds ratios varied from 1.41 for CUD to 1.73 for OUD.
