We have made all new data and knowledge publicly available by updating the KARG database [21]. Our study thus provides a 'dynamic' approach. We hope that this approach, as it stands, will provide a basis for meta-analyses of GWAS results of other diseases under the simple genetic architectures postulated herein, as well as a basis for consideration of meta-analytic approaches to more complex architectures in which the focus might be on genes in which variants that display differing frequencies in individuals with different genetic backgrounds are likely to be located. Such analyses could conceivably integrate both the idea of more population-specific variants with the rare variants that are being identified in disease and control samples through re-sequencing efforts.
