In this study, we report the first comprehensive meta-analysis of genetic association studies in drug addiction. We curated and integrated 212 candidate gene association studies and 5 GWAS. 843 vulnerable haplotypes were identified. We estimated the magnitude of the contributions of different molecular mechanisms to the effects of addiction susceptibility in one of the first 'post-GWAS' global attempts. We further found that at the levels of gene interaction networks, there was in fact good consistency between the genes identified by association studies and those identified by molecular biological studies of drug-regulated genes.
