other signaling event involved in LTD induction. The inhibitory effect of a CB1 agonist is lost following chronic ethanol consumption (Adermark et al., 2011), indicating that CB1 activity or a downstream mechanism is impaired. A few days abstinence following chronic ethanol exposure appears to be sufficient to restore eCB-LTD at striatal glutamatergic synapses (Xia, Li et al. 2006).
