The eCB-LTD observed at glutamatergic synapses in DLS is also impaired following chronic ethanol consumption (Adermark, Jonsson et al. 2011). This may involve a change in GABAergic tone at DLS synapses, but also appears to involve loss of CB1 agonist effects. It will be interesting to determine if the mechanisms of LTD loss at glutamatergic and GABAergic synapses are overlapping. It will also be important to learn if LTD at one or the other type of synapse is more sensitive to the effects of ethanol, as this will determine how the balance of striatal output is affected following chronic exposure.
