As shown in Table 7, by the time data collection had ended in 2019, the paths of the participants from case families continued to diverge from those of their counterparts from comparison families in numerous domains. This was observed in the substance use realm, where across all types of substances, use began at much younger ages, and prevalence estimates for disorders were 1.4 to over 4 times higher among those in case compared with comparison families. Excess prevalence in participants in case compared with comparison families was also observed for major depression, conduct disorder, and ASPD.
