The collaborative study on the genetics of alcoholism: Sample and clinical data.
paper
Primary
Public
- Authors
- Dick, Danielle M; Balcke, Emily; McCutcheon, Vivia; Francis, Meredith; Kuo, Sally; Salvatore, Jessica; Meyers, Jacquelyn; Bierut, Laura J; Schuckit, Marc; Hesselbrock, Victor; Edenberg, Howard J; Porjesz, Bernice; COGA Collaborators; Kuperman, Samuel; Kramer, John; Bucholz, Kathleen
- Year
- 2023
- Journal
- Genes, brain, and behavior
- PMID
- 37581339
- DOI
- 10.1111/gbb.12860
- PMCID
- PMC10550787
The collaborative study on the genetics of alcoholism (COGA) is a multi-site, multidisciplinary project with the goal of identifying how genes are involved in alcohol use disorder and related outcomes, and characterizing how genetic risk unfolds across development and in conjunction with the environment and brain function. COGA is a multi-generational family-based study in which probands were recruited through alcohol treatment centers, along with a set of community comparison families. Nearly 18,000 individuals from >2200 families have been assessed over a period of over 30 years with a rich phenotypic battery that includes semi-structured psychiatric interviews and questionnaire measures, along with DNA collection and electrophysiological data on a large subset. Participants range in age from 7 to 97, with many having longitudinal assessments, providing a valuable opportunity to study alcohol use and problems across the lifespan. Here we provide an overview of data collection methods for the COGA sample, and details about sample characteristics and comorbidity. We also review key research findings that have emerged from analyses of the COGA data. COGA data are available broadly to researchers, and we hope this overview will encourage further collaboration and use of these data to advance the field.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | Richard CD et al. | — | 2026 | → |
| Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts. | Choi M et al. | — | 2026 | → |
| Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk. | Poore HE et al. | — | 2026 | → |
| Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality. | Cooke ME et al. | — | 2026 | → |
| The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period. | Schuckit MA et al. | — | 2026 | → |
| Alcohol use disorders. | Rehm J et al. | — | 2025 | → |
| A Preclinical Alcohol Biobank: Samples from Behaviorally Characterized HS Rats for AUD Research. | Doyle MR et al. | — | 2025 | → |
| Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder. | Barr PB et al. | — | 2025 | → |
| Development of the Comprehensive Addiction Risk Evaluation System: Initial Participant Response to an Online Personalized Feedback Program Integrating Genomic, Behavioral, and Environmental Risk Information. | Dick DM et al. | — | 2025 | → |
| Frontal Theta Event-Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score. | Saenz de Viteri S et al. | — | 2025 | → |
| Parental Remission From Alcohol Use Disorder Shows Limited Protective Effects on Offspring Alcohol Outcomes. | McCutcheon VV et al. | — | 2025 | → |
| The effects of marital status, partner drinking, and sex differences on the likelihood of remission from alcohol use disorder. | Garasky C et al. | — | 2025 | → |
| The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample. | Kuo SI et al. | — | 2025 | → |
| Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report. | Hill SY et al. | — | 2025 | → |
| Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations. | Paul SE et al. | — | 2024 | → |
| Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank. | Lai D et al. | — | 2024 | → |
| Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms. | Neale ZE et al. | — | 2024 | → |
| DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction? | Ferraguti G et al. | — | 2024 | → |
| Personality in Alcohol and Opioid Use Disorder: A Multiphasic Personality Questionnaire Study. | Rana DK et al. | — | 2024 | → |
| Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data. | Ehringer MA | — | 2023 | → |
| Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder. | Miller AP et al. | — | 2023 | → |
| Specific diagnostic criteria identify those at high risk for progression from ‘preaddiction’ to severe alcohol use disorder | Miller AP et al. | — | 2023 | — |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |