The COVID‐19 pandemic required changes to the COGA protocol to ensure the health and safety of research participants and staff. These changes included the temporary suspension of all face‐to‐face evaluations in March 2020, with interviews conducted remotely and questionnaires filled out either via mailed paper versions or online via smartphone, computer, or tablet at a secure website. At several sites, in‐person laboratory testing (neurophysiological and computerized neuropsychological assessment batteries of cognition and emotion) resumed during periods when local infection rates were acceptably low. Interviews and questionnaires continued to be administered remotely. Beginning in August 2022, all sites eventually deemed it sufficiently safe, with appropriate screening and safety protocols in place, to resume in‐person assessment.