5 other cortical regions. In addition, it was reported that the subjects carrying the well-known AD-risk allele of APOE e4 have a significantly thinner cortex in the DLPFC compared to the APOE e2 carriers9. Thus, the DLPFC is a neocortical region that is a hub in cognitive circuits and is affected in AD. All available brains at the time of funding were used in each omic data generation from the DLPFC. Selection of subjects for genome-wide genotyping was different as that was performed from all self-reported non-Latino whites. Whole genome sequencing was limited to subjects with autopsy data. The data described in this report represent data that exist today and are available on Synapse. Numerous additional layers of data, including proteomic and metabolomic data, from tissue samples and purified cell populations are being produced and will become available as the data are finalized. We look forward to this large set of molecular and phenotypic data being repurposed by the neuroscience and other communities of researchers.
