Cataloguing multi-omic data in all of the ROSMAP subjects regardless of their disease trajectory can provide insight to the molecular events that contribute to aging-related cognitive decline. We generated complementary sets of data from the dorsolateral prefrontal cortex (DLPFC) of individuals in the study after their death. The primary function of the DLPFC is to control executive functions, including working memory and cognitive flexibility5, both of which are impaired during AD progression. Age-related increase in phosphorylated tau has been observed in the DLPFC6. A meta-analysis of 17 arterial spin labeling studies showed that AD patients have decreased regional cerebral blood flow in the DPLFC7. Further, the application of repetitive transcranial magnetic stimulation to the left DLPFC can improve cognitive function, behavior and functionality of AD patients8 that is comparable to improvement in cognitive performance from the treatment of subjects at 5 other cortical regions. In addition, it was reported that the subjects carrying the well-known AD-risk allele of APOE e4 have a significantly thinner cortex in the DLPFC compared to the APOE e2 carriers9. Thus, the DLPFC is a neocortical
