Inclusion criteria were age of 21-29 years, a body mass index between 19-30 kg/m2, and liver function test within 2 SD of normal limits. In addition, as used in our first cohort, candidates had to meet the study definition of a heavy social drinker [engaging in weekly binge drinking (5 or more drinks for males, 4 for females) 1-5 times/ week] and as defined by both SAMSHA (SAMHSA 2005) and NIAAA (NIAAA 2005). A weekly total drinks criterion (10-40 drinks/week) was included to ensure regular alcohol consumption.
