Participants in the second HD cohort were enrolled between 2009 - 2011 and all study procedures were approved by the University of Chicago Institutional Review Board. Recruitment methods, eligibility determination, and experimental procedures were identical to those employed for the original cohort (2004 – 2006; for details, see King et al., 2011a). In-person screening included written informed consent and completion of several questionnaires to determine demographics, health history, and drinking patterns. Candidates completed the Timeline Follow-Back Interview (Sobell et al., 1979); Quantity Frequency Interview (Cahalan et al., 1969) Beck depression inventory (Beck et al. 1961) and Spielberger Trait Anxiety Inventory (Spielberger et al., 1970) as well as a modified Structured Clinical Interview for DSM-IV (First et al., 2002) to assess lifetime mood, alcohol, and substance use disorders. Standard cut-off thresholds were utilized to exclude subjects with significant major current or past psychiatric illness (i.e., lifetime history of psychotic disorder, alcohol and other substance dependence, or a past year history of other Axis I disorders). Participants also underwent a brief physical examination, urine toxicology screen and pregnancy test (females), and a blood draw for liver enzyme levels.
