related to acute response in a combined sample of HD and LD (Brumback et al., 2007; King et al., 2011a; Roche and King, 2010), but we have yet to examine how FH relates to alcohol response in only HD. Therefore, the secondary goal was to examine whether FH affected acute response to alcohol in the original cohort of HD and to then attempt to replicate this pattern of response in a second cohort.