The primary goal of the current study was to ascertain identical subjective, objective, and performance responses to alcohol in a placebo-controlled laboratory study in an independent sample of HD and compare them to our previously published findings (Brumback et al., 2007; King et al., 2011a; Roche and King, 2010). The main experimental question was whether alcohol responses in a second HD cohort would directly replicate those previously observed in the original HD cohort. If the prior results were reproducible, this would provide confirmation that alcohol-induced increases in stimulation, liking, and wanting during the rising limb and peak breath alcohol content (BrAC), increases in sedation from peak BrAC through the declining limb, and marked performance impairments at peak BrAC characterize the alcohol response phenotype in young adult binge drinkers. Furthermore, in our original cohort, we have found little evidence that FH related to acute response in a combined sample of HD and LD (Brumback et al., 2007; King et al., 2011a; Roche and King, 2010), but we have yet to examine how FH relates to alcohol response in only HD. Therefore,
