The aims of the present study are: 1) To compare the associations of different FH measures (dichotomous and density) with behavioral and neural phenotypes of risk for AUD and 2) To examine if these associations vary across gender (between males and females) and race/ethnicity (between Whites and Blacks). We utilized data from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, multi-site, and multi-generational family study consisting of ethnically diverse AUD and community control families. COGA data comprise extensive assessments of individual family members with deep phenotyping in multiple domains (e.g., clinical, behavioral, neurophysiological). Also, information regarding each individual family member’s alcohol use, related behaviors, DSM-5 AUD symptom counts, and diagnoses have been acquired through direct interviews using the SSAGA, a poly-diagnostic psychiatric interview (Bucholz et al., 1994; Hesselbrock et al., 1999). These first-hand reports allow for greater reliability of the ascertained affectedness information and of FH measures derived from these reports. Therefore, taking advantage of COGA’s rich multi-modal AUD data, large ethnically diverse sample, and diagnostic information obtained via direct interviews, we computed four commonly used dichotomous
