Pretreatment with LPS significantly increased ethanol consumption during the initial period of intake in FVBxB6F1 mice as well as in B6xNZBF1 hybrids but not in FVB inbred mice (Fig. 6A, B and G). After alcohol deprivation, the increased ethanol intake was observed only in B6xNZBF1 hybrid mice (Fig. 6H and I). No differences between LPS- and saline-pretreated groups of FVB and FVBxB6F1 mice were found during the second period of drinking. Complete data for ethanol intake (amount of ethanol consumed, preference for ethanol and total fluid intake) in a two-bottle choice test for FVB, FVBxB6F1, and B6xNZBF1 female mice are presented in Supplemental Figs. 10–12 (for detailed statistics see Supplementary materials in Supplemental Table 5).
