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Chunk #33 — 3. Results — 3.2. Sensory perception of ethanol

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Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.
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Because the alcohol intake in the two-bottle choice paradigm depends on taste (Bachmanov et al., 2003), in the next experiments the effect of LPS pretreatment on consumption of sweet/noncaloric (saccharin) solutions, bitter (quinine) solutions, and sweet/caloric (sucrose) solutions were tested. Also, the possibility that LPS treatment may change the olfactory recognition of ethanol was tested. B6 mice of both sexes were used for all these experiments.