et al., 2010). In this previous study, Nsf was identified in an Ingenuity® pathway that included multiple glutamatergic and GABAergic receptor-associated genes (McBride et al., 2010). On the other hand, the higher expression of 2 genes (Cyr61 and Tnfrsf11b; Chen and Lau 2009; Hope et al., 2010) indicate that the level of alcohol drinking may be producing neuro-inflammation. Cyr61 is synonymous with CCN1 an extracellular matrix protein involved in Fas-mediated apoptosis (Juric et al., 2009). In addition, the Npy5r gene has been reported to be associated with both alcohol and cocaine dependence in human studies (Wetherill et al., 2008).
