Among the 26 genes in common between the Acb-sh and CeA (Table 2), 14 were up-regulated and 12 were down-regulated in the alcohol drinking group compared to the water control group. In general, several of the genes that had higher expression levels could result in enhanced neuronal function, involving intracellular transport (Kif15; Hirokawa et al., 2009) and cytoskeletal organization (Klhl23; Wu and Gong 2004), increased Kainate (Neto2; Copits and Swanson 2012) and NPY (Npy5r) receptor function, vesicle docking (Nsf; Ramakrishman et al., 2012), and mitochondrial function (Chchd5, Phb2, Slc25; Banci et al., 2009; Artal-Sanz and Tavernarakis 2009; Fiermonte et al., 2009). Kif15 is synonymous with kinesin-12 a cytoskeletal motor protein, which also affects axonal growth, navigation and branching (Liu et al., 2010). Nsf has been reported to be up-regulated in the CeA with chronic ethanol-drinking by adult P rats (McBride et al., 2010). In this previous study, Nsf was identified in an Ingenuity® pathway that included multiple glutamatergic and GABAergic receptor-associated genes (McBride et al., 2010). On the other hand, the higher expression of 2 genes (Cyr61 and Tnfrsf11b; Chen
