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Chunk #40 — Discussion

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Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.
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SNP selection, and also to select parameters for combining the two PRSs. We performed analyses mimicking their approach, by dividing the HCHS/SOL dataset to obtain training and validation datasets. However, this approach did not perform well, as determined by variance explained in WHI HA population. Details are provided in Section 2.2. of the Supplementary Material.