In summary, we reported a study about the construction of PRSs for use in general association studies performed in studies of admixed populations, specifically focusing on Hispanics/Latinos, based on results from independent GWASs in a large EA population, and in a small/medium Hispanic/Latino population. Our results indicate that current sample sizes of GWAS in Hispanics/Latinos are insufficient for good SNP selection, but utilizing EA GWAS for SNP selection and weights construction is useful. Importantly, we found that using only EA GWAS for constructing PRSs for blood pressure traits performs poorly in Hispanics/Latinos, with EA GWAS sample sizes of 70K individuals. While PRS construction depends on both sample size of discovery GWAS and genetic architecture, we hypothesize that as sample sizes in GWAS keep increasing, PRSs will become better, even when using only EA GWAS. We caution against using a reference panel that does not match a GWAS discovery population for SNP clumping. However, more flexible approaches for computing PRS weights are useful. We provide files with SNP selections and weights for our optimal PRSs validated in WHI HA and AA
