Next, we established a ‘multi-PGS’ model43 for BIP and SCZ, separately, by combining the psychotic-specific PGS with LCU- and CUD- PGSs in a joint model, accounting for the same covariates. This multi-PGS model was compared with the single-PGS model for the psychotic-specific PGS to evaluate the difference in explained variance due to the addition of PGSs for cannabis phenotypes.
