components may reflect putative difficulty in appropriately engaging reward, motivational, and emotional circuitry, which is consistent with perspectives suggesting that the transition from drug-use to addiction is driven by reduced functioning of reward systems, with concurrently increased activation of ‘anti-reward’ systems (Koob and Le Moal, 1997, 2005). Tomasi and coworkers (2010) arrived at similar conclusions when observing lower connectivity between midbrain dopaminergic regions and medial PFC regions in cocaine abusers (n=20) relative to healthy controls performing a sustained attention task.
