Alcohol component loading coefficient box plots for candidate CNV region at chromosome 11 q14.2. Deletion carriers have significantly, p < 0.05, higher median loading coefficients indicating these subjects contribute more to the alcohol use disorder severity component than insertion carriers or subjects with no variation. Similarly, insertion carriers have significantly, p < 0.05, lower loading coefficients indicating these subjects contribute less to the alcohol use disorder severity component than deletion carriers or subjects with no variation. Whiskers coincide with the box edges for hemizygous insertions.