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Chunk #40 — Fig. 4

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Association of genetic copy number variations at 11 q14.2 with brain regional volume differences in an alcohol use disorder population.
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Volume component loading coefficient box plots for candidate CNV region at chromosome 11 q14.2. There are 12 homozygous deletion carriers, 6 hemizygous insertion carriers and 265 subjects with no variation in this region. Deletion carriers have significantly, p < 0.05, higher median loading coefficients indicating these subjects have small cerebellar and caudate volumes and large 5th ventricle volume relative to insertion carriers and subjects with no variation. Similarly, insertion carriers have significantly, p < 0.05, lower median loading coefficients indicating they have large cerebellar and caudate volumes and small 5th ventricle volumes relative to deletion carriers or subjects with no variation. The central mark or each box represents the median with edges representing the 25th and 75th percentile respectively. The whiskers extend to the extreme non-outlier points. Whiskers coincide with the box edges for hemizygous insertions.