Chunk #8 — Problems of Successful Translation to Humans of Data from Animal Experimentation — The Discordance between Human Diseases and Animal Models of Diseases
treatments later to emerge was NXY-059, which proved effective in animal experiments. However, the drug failed in clinical trials, despite the fact that the set of animal experiments on this drug was considered the poster child for the new experimental standards.24 Despite such vigorous efforts, the development of STAIR and other criteria has yet to make a recognizable impact in clinical translation.25
