Chunk #18 — Materials and methods — Polygenic risk score phenome-wide and lab-wide association scans in BioVU

Source

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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To identify associations between POU PRS and biomarkers, we performed a LabWAS [36] in BioVU. We implemented the pipeline already established by Dennis et al. [36]. Broadly, LabWAS uses the median, INT-transformed age-adjusted values from the QualityLab pipeline in a linear regression to determine the association with the input POU PRS variable. We controlled for the same covariates as for the PheWAS analyses, excluding median age because the pipeline corrects for age using cubic splines with four knots.