As shown in Table 1, the estimated effects of all lead SNPs associated with depressive symptoms and neuroticism are in the range 0.020 to 0.031 SDs per allele (R2 0.02% to 0.04%). In the UKB cohort we estimated the effect of an additional allele of the chromosome 8 inversion polymorphism itself on neuroticism to be 0.035 SDs (Supplementary Table 13). The inversion explains 0.06% of the variance in neuroticism (roughly the same as the total variance explained jointly by the 6 SNPs in the inversion region).
