Another lead SNP associated with neuroticism, rs193236081, is located within a well-known inversion polymorphism on chromosome 17. We established that this association is attributable to the inversion polymorphism (Online Methods and Supplementary Note). Because this inversion yields only one significant locus and is genetically complex17, we hereafter simply use its lead SNP as its proxy. Our neuroticism GWAS therefore identified 11 lead SNPs, two of which tag inversion polymorphisms. A concurrent neuroticism GWAS using a subset of our sample reports similar findings18.
