For depressive symptoms, we identified two lead SNPs, indicated in the Manhattan plot (Fig. 1b). For neuroticism, our meta-analysis yielded 16 loci that are independent according to our locus definition (Fig. 1c). However, 6 of these reside within a well-known inversion polymorphism16 on chromosome 8. We established that all genome-wide significant signals in the inversion region are attributable to the inversion, and we confirmed that the inversion is associated with neuroticism in both of our neuroticism datasets, the GPC and the UKB (Online Methods and Supplementary Note). In our list of lead SNPs (Table 1), we only retain the most strongly associated SNP from these 6 loci to tag the chromosome 8 inversion.
