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Chunk #13 — Results — ABCB1

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Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
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There was a trend for different results among male and female patients regarding β-endorphin levels. Men with the minor allele TT tended to have higher β-endorphin levels (27.4 ± 3.40 fmol/L) than men with the major allele CC (25.8 ± 3.20 fmol/L). Similarly, women with the major allele CC tended to have higher β-endorphin levels (26.4 ± 3.30 fmol/L) than women with the minor TT allele (24.9 ± 3.66 fmol/L; Figure 2).