Next, we tested for each external phenotype whether the three rater-specific rgs with the external phenotypes could be constrained to be equal across mothers, teachers and self-ratings. For ADHD, ASD, MDD, schizophrenia, well-being, and self-reported health, constraining the rgs to be equal across rater resulted in significantly worse model fit (Supplementary Table 21). For all these phenotypes, rgs with teacher-reported AGG were consistently lower compared to mother- and self-reported AGG (Supplementary Fig. 7 and Supplementary Table 17). For lifetime cannabis use, genetic correlations also could not be constrained to be equal across raters. Here, a relatively strong rg was found with self-reported AGG (rg = 0.36; SE = 0.08) compared to teacher- (rg = 0.13; SE = 0.07) and mother-reported AGG (rg = 0.08; SE = 0.08).
