Empirical results from psychiatric genomics have begun to answer many fundamental questions. We point to two major unresolved issues. First, a crucial issue is pinpointing the biological implications of GWAS results. What precise mechanistic hypotheses arise from the findings? If a GWAS “associates” a psychiatric disorder to a specific genomic region, what genes should neuroscientists and molecular biologists study in order to delve more deeply into the basis of a disorder? This is crucial for downstream experimentation as studying one gene in detail can easily consume several personyears and hundreds of thousands of dollars.
