CSD methods have been effectively applied in alcoholism to elucidate topographical features and source activations distinguishing alcoholics or those at risk from control subjects (see Table 1, section 1), although there have been no such studies for other substance use disorders. CSD methodology has been used in combination with resting EEG, ERP, and ERO measures in a number of studies of individuals with alcohol use disorder (AUD), as well as in studies of high-risk offspring of alcoholic parents. Many of these studies of AUDs have used the local polynomial approximations method of calculating the surface Laplacian as proposed by Wang and Begleiter (1999), which is described in the Introduction section above.
