Tissue Specific Metabolism. Figure 4 summarizes tissue specific rates of glucose utilization R g′ (left panel), FFA utilization R f* (middle), and FFA clearance K f* (right). In the top row of this figure are “average tissue” glucose and FFA utilization rates (Rgav and R fav) which were obtained from the R^d and R fa data presented in Table 5 corrected for body weight. This data confirms that tesaglitazar treatment markedly ameliorated the impairment in insulin mediated switching of glucose and fatty acid utilization in the obese Zucker at the whole body level. Most importantly, a similar pattern is reflected in the R g′ and R f* profiles for muscle and white fat showing the quantitative importance of these tissues to whole body metabolism.
