A significant negative association between polygenic risk for alcohol dependence and performance on the verbal fluency test was observed (SAGE: β = −0.036, P = 0.0008; Yale‐Penn: β = −0.044, P = 0.00005) (Table 2). A significant negative association between Mill Hill Vocabulary and alcohol dependence polygenic risk was also found (SAGE: β = −0.027, P = 0.009; Yale‐Penn: β = −0.034, P = 0.001) although the SAGE P‐value did not withstand correction for multiple testing. Digit symbol coding was negatively associated with polygenic risk for alcohol dependence (SAGE: β = −0.029, P = 0.002; Yale‐Penn: β = −0.019, P = 0.04); however, the replication in the Yale‐Penn dataset is not significant after correction for multiple testing. All associations between PGRS and cognitive measures have been corrected for self‐reported alcohol consumption.
