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Chunk #11 — Methods — Quality Control

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Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
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Quality control procedures were carried out to ensure proper coding of variables across studies. Specifically, this was carried out by examination of univariate and multivariate distributions for phenotypic variables within each study, allele frequencies for SNPs, and conformity with Hardy-Weinberg Equilibrium (HWE).