account as well. Thus, imputed SNPs were unlikely to add a significant amount of information to this study and/or change the take home message. SNP proxies for applicable datasets are shown in Table 2. Information on r2 was obtained using Haploview HapMap II+III CEU [Barrett et al., 2005] and the 1000 Genomes Pilot 1 CEU [Abecasis et al., 2012]. SNP rs684513 was included due to associations with nicotine dependence [Winterer et al., 2010] and lung cancer risk [Amos et al., 2010]; its r2 is less than 0.8 with rs16969968, rs578776, and rs588765 in both Hapmap [Altshuler et al., 2010] and the 1000 genomes project (http://www.1000genomes.org) CEU data [Abecasis et al., 2012]. Linkage disequilibrium (as measured by r2) for all five loci is presented in Table 3. Allele frequencies for SNP proxies and target SNPs in each dataset are given in Table 1.
