The CNVR on chromosome 11q11 (CNVR 11q11) was the best CNVR (according to P-value in the family-based GWAS sample; min. Pfamily-based = 0.0047) among the set of 20 CNVRs which were directionally consistently associated with obesity in both GWAS discovery samples (with correlation coefficients up to r = 0.75 for pairs of associated CNV markers in the two samples; Table 2). CNVR 11q11 was similarly supported in the multi-marker analysis (min. P = 8.66 × 10−4; Fig. 3). This CNVR represents a locus previously not reported to be associated with obesity. It is located between 55 130 596 and 55 210 165 bp spanning ∼80 kb. Interestingly, the region exclusively covers three olfactory receptor (OLR) genes: OR4P4, OR4S2 and OR4C6 (according to RefSeq of UCSC hg18; http://genome.ucsc.edu/) all belonging to the OLR family 4.
