period, at the all-risk level, taking into account risk mediation at the most detailed cause level. The contribution of changes in exposure for the individual risks was scaled to the all-risk effect at the most detailed outcome level. The contribution of risk exposures over longer time periods—eg, 2000–16—or at higher cause aggregates—eg, all cause—were calculated as the linear aggregate of the effect of individual risks at the most detailed cause level and time period.