The effects of ethanol in the CNS are very complex and likely to produce a number of alterations at the cellular level. In order to better understand the complex actions of ethanol at both the behavioral and cellular level, it is important to have multiple experimental approaches. One approach is to study one system at a time with a well-defined and focused hypothesis. An alternative is to take a much broader approach, using genomics and proteomics tools to obtain more information, which could better define the effects of ethanol at multiple cellular and biological systems levels. There have been several studies that applied genomics (mainly) and proteomics analyses to examining the effects of ethanol in rodent models and post-mortem human tissue (Alexander-Kaufman et al., 2006, 2007; Bell et al., 2006; Flatscher-Bader et al., 2005; Kerns et al., 2005; Lewohl et al., 2000, 2004; Liu et al., 2004; Matsumoto et al., 2007; Mayfield et al., 2002; Rodd et al., 2008; Saito et al., 2002, 2004; Treadwell and Singh 2004). The studies conducted on post-mortem human tissue measured the consequences of long-term
