We have presented evidence that multiple factors known to be intimately involved in AD pathogenesis are now being shown to modulate adult neurogenesis. Most notably PS1 and APP are emerging as a critical player in these processes. Conversely, multiple factors known to be involved in neurogenesis are emerging as critical players in AD pathogenesis. These include Wnt/Notch and reelin signaling. This convergence of signaling should be taken into account in the development of potential therapies.
