We performed LD-score regression to determine the additive heritability attributed to the genome-wide SNPs. The heritability from the WW sample on the observed scale is 0.326 (SE = 0.043, unconstrained, intersect 0.97 (0.007), liability scale h 2 (assuming population prevalence of 1%; 0.18 (SE = .02)). This estimate was based on data from 1095,173 high-confidence SNPs, which show an association inflation, Lambda = 1.06. For the European ancestry samples, the heritability estimate is nearly identical (1,081,358 SNPs; observed scale h 2 = 0.334 (SE = 0.035; unconstrained; intersect 0.99 (0.008); liability scale h 2 (assuming population prevalence of 1%; 0.19 (SE = .02); Lambda = 1.07)). Both estimates are consistent with previous PGC-based estimates of SNP heritability from a subset of these data (liability scale h 2 = 0.17 (SE = 0.025) [46]).
