Using the noSWM3 ASD data and the summary GWAS data from the PGC schizophrenia study, we estimate the genetic correlation between ASD and schizophrenia at approximately 23% (genetic correlation (Rg) = 0.23 (SE = 0.05); P = 9 × 10−6; total liability scale genetic covariance = 0.09 (SE 0.02)). This genetic covariance is almost threefold larger than previous reports [47]. As a null comparison, we estimated the genetic correlation against the unrelated Rheumatoid Arthritis GWAS and found no significant correlation with ASD.
