We also tested whether the genes associated with alcohol dependence were differentially affected by ethanol exposure in LCLs. Forty of the SNPs listed in Table 2 were in genes expressed in brain and also significantly affected by ethanol in LCLs. One of the SNPs in CARS, rs729662 (synonymous, Pro706 in exon 19), was ranked 80 in the GWAS and was also significant in the family data (Supplemental Table 1).
