Fifteen of the SNPs with the smallest p values for alcohol dependence (p ≤ 2.1 × 10−4) provided nominal evidence of association in the family sample with the early onset alcohol dependence phenotype. In addition to the SNPs noted above, these included SLC37A3, KCNMA1, CDH8, ZNF608 and API5. A few candidate genes in which a SNP had p≤2.1 × 10−4 in the GWAS or cluster of SNPs with p≤10−3 were also tested in families, and significant support was found for CAT, and GRIN2C (Supplementary Table 1).
