Ten of the 180 SNPs genotyped in the sample of 262 genetically informative, alcohol dependent families provided nominally significant (p ≤ 0.05) evidence of association with alcohol dependence (Table 2, Supplementary Table 1); 8 of these were also nominally significant for the early onset phenotype. Five of these SNPs lie in one region of chromosome 11 (Figure 2A), which contained CARS (all 3 tested SNPs replicated), OSBPL5, NAP1L4. The other SNPs were in BBX, SLC9A8, OPA3, TOX2, and near CD53. Several additional SNPs near other clusters of significant SNPs were also genotyped and also provided evidence for association (Supplementary Table 1), including additional SNPs in and near CARS, OSPBL5, SLC9A8, SLC2A14, SOX5, COL8A1 and ADCK1.
