Data from the AA case control sample provided nominal evidence of association for DSM-IV alcohol dependence for six SNPs among the top 985 from European Americans; these were in TMEM132C, EPHA7, OPA3, KCNMA1 (encoding a potassium large conductance calcium-activated channel important in neuronal excitability), DMRTA2 and SPTA1 (Supplementary Table 1). EPHA7 encodes ephrin receptor A7; ephrin receptors are tyrosine kinases implicated in the development of the nervous system. A secondary analysis of the smaller AA sample showed a different set of SNPs that provided evidence for association with alcohol dependence (Supplementary Table 2). Among the 790 SNPs at p≤ 10−3, 41 were nominally significant in the EA group; prominent among them were 7 SNPs (several, but not all, in high LD) in the region of SELL and SELE, two selectins (adhesion/homing receptors), 4 in LOC91431, encoding the protein prematurely terminated mRNA decay factor-like, and SNPs in PPARG (peroxisome proliferator-activated receptor gamma), CTNN2 (catenin, alpha 2). Also of note is a SNP between the leptin receptor (LEPR) and PDE4B, a cAMP-specific phosphodiesterase that has been implicated in schizophrenia and bipolar disorder.
