in ascertained case-control studies like the Psychiatric Genomics Consortium (Walters et al., in preparation). The aim of the present study was thus to investigate whether there may be differences in the genetic liability for alcohol problems across two sample types: unselected, population-based epidemiological cohorts and clinically ascertained families densely affected with AUDs. To test this hypothesis, we use polygenic risk scoring methods to predict aggregate genetic risk for AUD symptoms across four independent birth cohort or clinically ascertained samples with in-depth clinical assessments of AUDs.
