Therefore, we examined whether GABRR1 and GABRR2 might be associated with alcoholism. We genotyped 73 SNPs, covering GABRR1, GABRR2, and their flanking regions, in a sample of European Americans from families in which at least three first-degree relatives were alcohol dependent. We report here evidence that SNPs in both GABRR1 and GABRR2 were significantly associated with alcohol dependence.
